This project proposes a bottom-up, holistic approach to develop efficient colloidal nanovectors that can deliver therapeutic RNA for anti-viral treatments. Novel ionizable, cleavable and biocompatible surfactants will be chemically synthesized to create rationally designed formulations, that will be characterized and tested for their capacity to encapsulate/compact different types of RNA. The most promising RNA/nanovectors will then be validated in experimental cell models.(DOI: 10.54499/2022.05543.PTDC)
