HyPerRem introduces a novel hybrid water-treatment approach for PFAS that combines photocatalysis and bioremediation. Addressing the persistence and bioaccumulation of PFAS, this method uses 3D-printed multilayer photocatalytic membranes and bacterial catabolism to maximise defluorination and degradation of PFAS in water, thereby reducing environmental impact. The process's scalability will be assessed to support industrial optimisation.