Like plants and animals, microbes have also been domesticated but our knowledge of the genetics of these transformations is very incomplete. Key steps of Saccharomyces cerevisiae domestication have been uncovered but major questions remain unanswered. We propose a new conceptual framework in which domestication, rather than a linear change from a wild state to a domesticated one, is a multi-scale evolutionary process that involves compound and independent events and persistent contact between wild and domesticated lineages. Three fundamental questions will be addressed: 1 are regional breeds recognizable at the genomic and phenotypic level? 2 do some complex and poorly known lineages, like that of cachaça yeasts in Brazil, result from secondary rounds of domestication? 3 is the emergence of virulence a consequence of domestication and exadaptation, combined? This study will bring a fine grained genomics picture of regional variants and a new global perspective to microbe domestication.
Total: 232,496.32 €
CBMA: 8,150.00 €
NOVA.ID.FCT – Associação para a Inovação e Desenvolvimento da FCT (NOVA.ID.FCT/FCTUNL/UNL)
Instituto Nacional de Investigação Agrária e Veterinária, I.P. (INIAV)